Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production
نویسندگان
چکیده
منابع مشابه
Lysine Catabolism: Flow, Metabolic Role and Regulation
Lysine is an essential amino acid, synthesized in plants in the aspartic acid pathway. The lysine catabolism is performed by the action of two consecutive enzymes, lysine 2-oxoglutarate reductase (LOR) and saccharopine dehydrogenase (SDH). The steady state of lysine is controlled by both, synthesis and catabolism rates, with the final soluble lysine concentration in cereal seeds a direct result...
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The labeling patterns found in tissue glutamate, aspartate, and alanine after administration of glutaric acid-3-Cl4 to male rats (1) indicated that the major catabolic route of glutarate is via acetate (2) and not via a direct conversion to the carbon chain of cu-ketoglutarate (3-5). In further studies on the metabolism of glutarate-3-C14 in rats, we have observed the formation of urinary acety...
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Lysine is frequently a first- or second-limiting amino acid in poultry diets. Improving the efficiency of lysine use for protein synthesis would effectively lower the lysine requirement and decrease feed costs. Understanding how lysine is degraded and how the degradation is regulated would identify potential molecular targets for interventions to decrease lysine degradation. To better understan...
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Lysine is an essential amino acid for mammals but its concentration in cereals, one of our main food sources, is low. Research over the past 40 years has unraveled many biochemical and molecular details of the aspartic acid pathway, which is the main route of lysine biosynthesis in plants. However, genetic manipulation of this pathway has not been successful at producing high-lysine seeds. This...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2019
ISSN: 2041-1723
DOI: 10.1038/s41467-019-11289-4